Ever, by being in the Formulary, yet restricted, the promotion of these agents was not limited. This policy has been changed. Now drug reps cannot promote restricted drugs in the hospital setting. Indiscriminate promotion of restricted drugs was not rational and was inconsistent with the logic that caused the P&T Committee to designate the drugs as restricted. The Department of Pharmacy Services is responsible for enforcing the Guidelines for Drug Manufacturers' Sales Representatives. The Director of Pharmacy Services enforces infractions of this policy in a step-wise manner per infraction. This could lead to a suspension from the hospital for 3 to 6 months. The policy states that, at the Director's discretion, further disciplinary action could be taken following any infraction. If you notice this policy being violated, it is your responsibility to notify the Director of Pharmacy 265-0404.
Detroit - Wayne State University Gyula Acsadi, M.D., Ph.D. RG ; Gene therapy for spinal muscular atrophy SMA ; $ 85, 730 1 - Year 2 $ 84, 062 1 - Year 3 Summary SMA is the most prevalent genetic motor neuron disease of humans. There is no effective therapy available. The primary defect in SMA is related to the loss of spinal motor neurons due to a genetic defect in the survival motor neuron gene. Researchers propose a gene therapy approach to deliver trophic molecules to spinal cord motor neurons as well as to carry out SMN1 gene replacement in recently developed trasngenic mouse models of SMA. RG ; Gene therapy for amyotrophic lateral sclerosis ALS ; by AAV mediated gene transfer $ 88, 568 1 - Year 1 $ 91, 095 1 - Year 2 $ 93, 696 1 - Year 3 Summary Currently, there is no effective therapy for ALS. Neurotrophic factors have the potential to promote motor neuron survival. However, systemic administration of trophic factors has been unsuccessful in ALS. The experimental strategy in this grant is focused on a gene therapy approach to find a safe and efficient method to delier therapeutic factors at the site of injury, the lower motor neurons. This grant aims at the optimization of AAV mediated gene therapy in the SOD1 mouse and rat model for ALS. Michael Shy, M.D. RG ; Adeno associate virus gene therapy for Charcot-Marie-Tooth CMT ; $ 97, 983 7 - Year 2 Summary CMT1 is one of the most common inherited neuromuscular diseases. Currently there is no treatment for CMT1. Researchers propose to use a portion of a benign virus to introduce genes for a growth factor, GDNF, into nerves of a mouse model of CMT1 to both prevent nerve degeneration and promote nerve regeneration. East Lansing - Michigan State University William Atchison, Ph.D. RG ; Unmasking of L type CA channels in ACh release in Lambert-Eaton syndrome LEMS ; $ 76, 920 1 - Year 1 $ 79, 224 1 - Year 2 Summary In LEMS, release of chemical messenger acetylcholine between nerve and muscle is disrupted. A critical protein controlling entry of calcium into the nerve is thought to be the target in LEMS. The goal of this tudy is to identify the protein targets in LEMS by treating mice, in which the gene expressing the component parts of this protein is mutated, with antiodies of patients with LEMS, and examining their neuormuscular function.
Presented to the: national medical scientific meeting, dublin 199 poster.
ANTIRETROVIRALS NRTIs- abacavir Ziagen ; , abacavir lamivudine zidovudine Trizivir ; , didanosine ddI, Videx ; , lamivudine Epivir, 3TC ; , lamivudine zidovudine Combivir ; , stavudine d4T, Zerit ; , tenofovir Viread ; , zalcitabine ddC, HIVID ; , zidovudine AZT, Retrovir ; . PIs- amprenavir Agenerase ; , indinavir Crixivan ; , lopinavir ritonavir Kaletra ; , nelfinavir Viracept ; , ritonavir Norvir ; , saquinavir Fortovase, Invirase ; . NnRTIs- delavirdine Rescriptor ; , efavirenz Sustiva ; , nevirapine Viramune ; . Other- hydroxyurea Hyfrea ; . OI DRUGS PHS "A1 OI"s- acyclovir Zovirax ; , azithromycin Zithromax ; , cidofovir Vistide ; , clarithromycin Biaxin ; , famciclovir Famvir ; , fluconazole Diflucan ; , foscarnet Foscavir ; , ganciclovir Cytovene ; , itraconazole Sporonox ; , leucovorin, pyrimethamine, sulfadiazine, TMP SMX Bactrim, Cotrim, Septra ; . Other OIs- amphotericin B Fungizone ; , atovaquone Mepron ; , ciprofloxacin Cipro ; , clindamycin, clotrimazole Mycelex ; , dapsone, ethambutol Myambutol ; , formivirsen Vitravene ; , ketoconazole Nizoral ; , ofloxacin Ocuflox ; , pentamidine Nebupent, Pentam ; , primaquine, rifabutin Mycobutin ; , valacyclovir Valtrex ; . Hepatitis C- none. TREATMENTS FOR METABOLIC DISORDERS Cardiac- enalapril Vasotec ; , furosemide Lasix ; , hydrochlorothyazide, nifedipine Procardia ; , quinapril Accupril ; . Diabetic- insulin syringes, metformin Glucophage ; . Hyperlipidemia- atorvastatin Lipitor ; , fenofibrate Tricor ; , gemfibrozil Lopid ; . Wasting- megestrol acetate Megace ; , testosterone Testoderm, Delatestryl, Androderm ; . ALL OTHERS albuterol Airet, Proventil, Ventolin, Volmax ; , alprazolam Xanax ; , amitriptyline Elavil ; , bupropion Wellbutrin, Zyban ; , buspirone Buspar ; , cetrizine Zyrtec ; , diphenoxylate Lomotil ; , doxycycline Monodox ; , erythromycin, famotidine Pepcid ; , fexofenadine Allegra ; , fluoxetine Prozac ; , gabapentin Neurontin ; , hepatitis A Vaccine, hepatitis B Vaccine, influenza Vaccine, lansoprazole Prevacid ; , laratadine-pseudoephedrine Claritin ; , levofloxacin Levaquin ; , loperamide Imodium ; , lorazepam Ativan ; , nicotine Nicotrol, Habitrol, NTC ; , omeprazole Prilosec ; , paroxetine Paxil ; , pneumococcal Vaccine Pneumovax ; , prochlorperazine Compazine ; , rimantadine Flumadine ; , Respirgard II Nebulizer ; , setraline Zoloft ; , trimethobenzamide Tigan ; , zolpidem Ambien.
Gleevec hydrea
That the difference in AUC between the hydrea use for MSH's study and hydrea is about 2-fold. It may be due to.
After the atomization the graphite tube and the iridium coating are cleaned in an additional heating step with the purge gas on, so that there is no risk for any carry-over. Care has to be taken only that this cleaning temperature does not exceed the volatilization temperature of iridium. The life time of iridium coated tubes is similar to that of pyrolytically coated graphite tubes. The HydrEA technique can be used in continuous flow or in batch mode and dilantin.
Hydroxyurea hydrea ; compared with methotrexate and cyclosporine, hydroxyurea is somewhat less effective.
Linkage with Time-scale other objectives 20002005 KKM 6 000 not covered KKM 6 000 partly likely RE RE Principal and Other responsible parties Man power Cost requirement x1000 EEK man year Current funding Possible sources of funding Priority I - max III - min I II 20002005 KKM KKM KKM KKM, EPM KKM, ITK, EPM, T 2 1 3 000 1 800 150 KKM, ITK, KKI KKM 20012002 20002001 KKM, EPM, T KKM, ITK, T, EPM 0.5 3 0.7 000 80 1 000 200 400 1 000 20002005 19992005 KKM, TA KKM HM, KKM not covered 40% likely 40% likely 75% covered not covered partly likely not covered not covered not covered not covered 50% likely 50% likely not covered not covered RE, KF, VA, EK II VP, KF VP, RE II I RE, KK, KF, VP I RE, KF, VP RE, KF, VP, RE, KF RE, KF, VP KF, RE RE, KF, VP RE, ETF, VP KF, RE RE, KF, VP KF partly covered KF, RE, VP II II II III II KKM 1 KKM, TA, ITK, T, EPM 1 KKM, ITK, T, EPM 2 20002002 20002001 KKM, EPM, T KKM , EPM, T 0.3 2 150 not covered not covered KF, VP KF, ETF, VP II I I III 30 10 16 and docusate.
New drugs added since June 2002 indicated in bold. ANTIRETROVIRALS NRTIs- abacavir Ziagen ; , abacavir lamivudine zidovudine Trizivir ; , didanosine ddI, Videx , Videx EC ; , lamivudine Epivir, 3TC ; , lamivudine zidovudine Combivir ; , stavudine d4T, Zerit ; , tenofovir Viread ; , zalcitabine ddC, HIVID ; , zidovudine AZT, Retrovir ; . PIs- amprenavir Agenerase ; , indinavir Crixivan ; , lopinavir ritonavir Kaletra ; , nelfinavir Viracept ; , ritonavir Norvir ; , saquinavir Fortovase, Invirase ; . nNRTIs- delavirdine Rescriptor ; , efavirenz Sustiva ; , nevirapine Viramune ; . Other- hydroxyurea H6drea ; . OI DRUGS PHS "A1 OI"s- acyclovir Zovirax ; , azithromycin Zithromax ; , cidofovir Vistide ; , clarithromycin Biaxin ; , famciclovir Famvir ; , fluconazole Diflucan ; , foscarnet Foscavir ; , ganciclovir Cytovene ; , isoniazid generic ; , itraconazole Sporonox ; , leucovorin calcium Wellcovorin ; , pyrimethamine Daraprim ; , sulfadiazine oral generic ; , TMP SMX Bactrim, Septra ; . Other OIs- albendazole Albenza ; , amikacin sulphate generic injection ; , amoxicillin trihydrate oral generic ; , amphotericin B Fungizone ; , atovaquone Mepron ; , bleomycin sulfate Blenoxane ; , ciprofloxacin Cipro ; , clindamycin Cleocin ; , clofazimine Lamprene ; , clotrimazole Lotrimin, Mycelex ; , cyclophosphamide Cytoxan ; , dapsone Avlosulfon ; , dexamethasone Decadron ; , doxorubicin Adriamycin ; , epoetin alpha Procrit ; , ethambutol Myambutol ; , filgrastim Neupogen ; , flucytosine 5FC, Ancobon ; , fomivirsen Vitravene ; , ketoconazole Nizoral ; , isoniazid rifampin generic ; , liposomal duanorubicin DaunoXome ; , methotrexate oral, injection ; , metronidazole oral generic ; , nystatin Mycostatin ; , paclitaxel Taxol ; , paromomycin Humatin ; , pentamidine Nebupent, Pentam ; , prednisone oral generic ; , pyrazinamide generic ; , rifabutin Mycobutin ; , rifampim generic ; , trimethoprim Trimpex, Proloprim ; , trimetrexate glucuronate NeuTrexin ; , valganciclovir Valcyte ; , valacyclovir Valtrex ; , vinblastine sulfate Velban ; , vincristine sulfate Oncovin ; . Hepatitis C- interferon alfacon 1 Infergen ; , interferon A-2A Intron-A, Roferon-A ; , ribavirin generic ; , ribavirin interferon alpha 2B Rebetron ; . TREATMENTS FOR METABOLIC DISORDERS Diabetic- glipizide Glucotrol ; , rosiglitazone maleate Avandia ; . Hyperlipidemia- atorvastatin Lipitor ; , gemfibrozil generic only ; , pravastatin Pravachol ; , simvastatin Zocor ; . Wasting- dronabinol Marinol ; , megestrol acetate Megace ; , nandrolone Durabolin, Deca-Duranbolin ; , oxandrolone Oxandrin ; , somatropin Serostim ; , testosterone generic injection, transdermal ; . ALL OTHERS alitretinoin gel Panretin Gel ; , alprazolam Xanax ; , amitriptyline hydrochloride generic ; , bupropion HCL Wellbutrin ; , buspiron HCL BuSpar ; , cephalexin oral generic ; , citalopram hydrobromide Celexa ; , codeine w wo ASA, APAP oral generic ; , desipramine HCL oral generic ; , dicloxacillin sodium oral generic ; , diphenoxylate HCL Lomotil ; , divalproex sodium Depakote ; , doxycycline hyclate oral generic ; , erythromycin oral generic ; , famotidine generic ; , fenoprofen calcium oral generic ; , fentanyl Duragesic, hospice clients only ; , fluoxetine HCL Prozac ; , gabapentin Neurontin ; , hepatitis A vaccine, hepatitis B vaccine, hydrocodone w wo APAP oral generic ; , ibuprofen-prescription strength generic ; , imiquimod Aldara ; , indomethacin oral generic ; , ketoprofen oral generic ; , ketorolac tromethamine Toradol injection ; , lamotrigine Lamictal ; , lansoprazole Prevacid ; , levorphenol tartrate Levo-Dromoran ; , loperamide HCL generic ; , lorazepam oral generic ; , methadone HCL oral generic ; , metoclopramide Reglan, Clopra ; , minocycline HCL oral generic ; , morphine sulfate oral generic ; , naproxen oral generic ; , nefazodone HCL Serzone ; , neomycin sulfate oral generic ; , nortriptyline HCL oral generic ; , olanzapine Zyprexa ; , omeprazole Prilosec ; , opium, tincture of, oxycodone w wo ASA, APAP oral generic ; , pancrelipase Ultrase ; , paroxetine HCL Paxil ; , penicillin V potassium oral generic ; , pneumococcal vaccine Pneumovax, Pnu-Immune ; , probenecid generic ; , prochlorperazine Compazine ; , promethazine Phenergan ; , quetiapine fumarate Seroquel ; , ranitidine HCL prescription strength generic ; , risperidone Risperdal ; , sertraline Zoloft ; , sulindac oral generic ; , tetracycline HCL oral generic ; , trazodone HCL oral generic ; , vancomycin HCL oral generic ; , venlafaxine HCL Effexor.
7. Agarwal RP, McPherson RA, Phillips M. Rapid degradation of disulfirain by serum albumin. Res Coinrnun Chem Pathol Pharmacol 1983; 42: 293-310 and zometa.
Manufacturer bristol-myers squibb withholds comment because hydrea is not fda-approved for the treatment of hiv.
05 03 the committee on safety of medicines csm ; issue further data on the safety of thiomersal in vaccines source committee on safety of medicines csm ; : on 12 february 2003, the csm considered further evidence, which supports the safety of thiomersal which contains ethylmercury ; in vaccines and lamictal.
The first and most obvious source of additional participants is the practice of physicians in the same group as the PI. Given the current clinical environment, the associates of the study's PI sometimes forget or are unaware of randomized clinical trials, and as such, awareness within the practice or department should be reinforced regularly. This reinforcement needs to be both prospective and retrospective. Prospective efforts include reports of study progress at group meetings to heighten awareness and having study materials and reminders prominently displayed. It is also likely that some potential participants will fail to be screened. The CRC should periodically perform chart reviews to ensure that all potential participants are referred. If potential participants are missed, the CRC should encourage the study PI to discuss particular participants with his her associates and stress the importance of the study to the group. The CRC should be aware of the referral rates of members of the practice, and especially make the PI aware of physicians that chronically fail to refer potential participants. With the current clinical environment, recruiting participants from beyond the practice is a particular challenge. However, community physicians can successfully be approached to refer potential participants if the need to enroll and monitor participants is separated from their care as patients. Specifically, the study is not requesting that potential participants be referred to the study PI, but rather that they are allowed to participate in a clinical research program. The primary care of the patient can remain under the direction of the community physician; however, the participant must abide by the treatment protocol. The participant must attend evaluations in the study clinic, but may also be seen by the community physician. More importantly, the potential participant is being asked to participate in the study for a finite period of time active treatment for two weeks with two additional follow-up visits ; , and the community physician can be assured that all care of the participant will be returned to the community physician beyond that point. Finally, advantages to the community physician should be stressed. These include providing the most current care to their patients and the value of being associated with the leading edge of treatment for a complex disease. These are difficult and time-consuming relationships to develop and foster; however, the opportunity to expand the recruitment net may well be an important and fruitful effort. It is likely that clinic staff will become aware of potential participants in the daily course of operations. All patients suspected of SSNHL should be pursued and evaluated. In most instances, the physician will have already explained the study to the potential participant. Upon being found eligible through pre-screening, the potential participant will be contacted by the CRC to invite him her to participate in the study. The potential participant will be scheduled for a screening and enrollment visit where he she will sign the consent form and be screened to ensure compliance with all eligibility criteria. If the potential participant is eligible and willing to participate, he she will be randomized into the study. At this visit, the participant will complete the necessary study questionnaires, undergo audiometric evaluations, and, if not yet done, have testing to rule out retrocochlear disease. Baseline laboratory tests will include HCT, WBC, serum glucose, and, if indicated, a pregnancy test. At the discretion of the Clinical Site PI and based upon intake medical history, other diagnostic laboratory tests may include: PPD Hepatitis screen Syphilis screen.
Sur ger y for in vasive br east can cer 4.1 4.2 4.3 Breast conserving surgery Total mastectomy Comparison of breast conserving surgery with mastectomy Management of the axilla Breast reconstruction External breast prostheses Complications of surgery The economics of locoregional therapy Practice audit and nitrofurantoin.
Generic Name Abacavir ABC ; Didanosine ddI ; Lamivudine 3TC ; Stavudine d4T ; Zalcitabine ddC ; Zidovudine AZT ; AZT plus 3TC Indinavir Nelfinavir Ritonavir Saquinavir Efavirenz Nevirapine Hydroxyurea Proprietary or Brand Name Ziagen Videx Epivir Zerit Hivid Retrovir Combivir Crixivan Viracept Norvir Invirase Sustiva Viramune Hydrsa Drug Class NRTI NRTI NRTI NRTI NRTI NRTI NRTI PI PI PI NNRTI NNRTI Modulator Daily Dose 70kg adult 600 mg 250 mg 300 mg 60 mg 2.25 mg 600 mg 600 + 300 2400 mg 2250 mg 1200 mg 600 mg 600 mg 200 mg 1000 mg Cost in US$ for 3 Months 950-1200 420-700 690.
Sydenham's chorea: magnetic resonance imaging of the basal ganglia and imodium.
Spell D W. Long-term use of hydroxyurea for sickle cell anemia. JAMA 2003; 290 6 ; : 752; author reply 754 No Original Data Spier S, Solomon L M, Esterly N B et al. Hydroxyurea and macrocytosis. Br J Dermatol Not relevant to key questions, study size too small Squibb hydroxyurea Hyrdea ; . Clin Pharmacol Ther 69; 10 1 ; : 142-6 No Original Data, Not relevant to key questions Stagno F, Guglielmo P, Consoli U et al. Successful healing of hydroxyurea-related leg ulcers with topical granulocyte-macrophage colony-stimulating factor [2]. Blood 99; 94 4 ; : 1479-1480 Not relevant to key questions Stavroyianni N, Stamatopoulos K, Viniou N et al. Autoimmune hemolytic anemia during alpha ; interferon treatment in a patient with chronic myelogenous leukemia. Leuk. Res. 2001; 25 12 ; : 10971098 Not relevant to key questions, No Original Data Steensma D P, Harrison C N, Tefferi A. Hydroxyureaassociated platelet count oscillations in polycythemia vera: a report of four new cases and a review. Leuk Lymphoma Not relevant to key questions Steinberg M H. Pneumococcus and sickle cell disease: The beginning of the end?. Clin. Infect. Dis. 2007; 44 11 ; : 1434-1435 No Original Data Stolbach L L, Begg C B, Hall T et al. Treatment of renal carcinoma: a phase III randomized trial of oral medroxyprogesterone Provera ; , hydroxyurea, and nafoxidine. Cancer Treat Rep 81; 65 7-8 ; : 689-92 Study size too small Strauss R G. Sickle cell patients deserve controlled recommendations. Transfusion 2002; 42 5 ; : 658-9; author reply 659-60 No Original Data Streetly A, Dick M, Layton M. Sickle cell disease: the case for coordinated information. BMJ 93; 306 6891 ; : 14912 No Original Data Stuart A, Jones S M, Walker L J. Insights into elevated distortion product otoacoustic emissions in sickle cell disease: comparisons of hydroxyurea-treated and nontreated young children. Hear Res 2006; 212 1-2 ; : 83-9 Not relevant to key questions, study size too small Sualdea Montes M, Pedraza Cezon L, Martinez Nieto C et al. Compassionate use of hydroxyurea in the treatment of meningioma. Other.
Your account browse by categories allergy allegra astelin atarax clarinex claritin elimite cream lioresal nasacort nasonex periactin rhinocort aqua zyrtec anti convulsants lamictal mysoline neurontin tegretol topamax trileptal valparin anti depressants anafranil asendin bupropion xl wellbutrin ; buspar celexa cymbalta desyrel dilantin effexor elavil geodon lexapro lithobid luvox pamelor paroxetine paxil ; prozac remeron risperdal sinemet sinequan tofranil trivastal zoloft zyprexa anti fungal diflucan fulvicin grisactin lamisil nizoral sporanox anti narcoleptic modalert anti viral famvir 250 mg rebetol symmetrel valtrex videx zovorax 400mg acyclovir ; virazole zerit ziagen anti-oxitant suppliments anti-oxitant vitamin mineral antibiotics amoxicillin ampicillin bactrim biaxin ceclor ceftin cipro cleocin dapsone duricef floxin ilosone keflex levaquin macrobid minomycin myambutol rulide sumycin suprax tegopen vantin vibramycin zithromax arthritis ansaid arava arcoxia relafen zyloprim asthma brethine ketotifen pulmicort singulair blood pressure aceon adalat adalat-sr aldactone altace atacand avapro calan capoten cardizem cardura coversyl cozaar diltiazem diovan frumil gemfibrozil hytrin hyzaar inderal lopressor lotensin lotrel lozol microzide minipress normadate norvasc plavix plendil tenoretic tenormin toprol-xl tritace vasotec verapamil zebeta zestoretic zestril cancer casodex cytoxan eulexin hydrea methotrexate nolvadex trecator sc vepesid cardiovascular cardarone coumadin lanoxin mextil norpace rythmol cholesterol crestor lipitor lopid mevacor pravachol tricor zetia zocor diabetes actos amaryl avandia ddavp glucophage glucotrol novonorm prandin precose rocaltrol diuretics lasix ziac gastrointestinal aciphex albenza biltricide carafate cimetidine colospa flagyl imodium metoclopramide motilium nexium pepcid phenergan prevacid prilosec protonix ranitidine reglan zelnorm hair care finasteride finpecia ; propecia proscar herpies anti-viral valtrex mens health cialis cialis soft flomax levitra sildenafil caverta ; sildenafil kamagra ; sildenafil silagra ; tadalafil forzest ; tadalafil tadacip ; tadalafil tadalis ; viagra viagra soft tabs migraines depakote imitrex muscle relaxers skelaxin zanaflex nausea antivert comapazine dramamine maxolon other alfacip aralen arcalion asacol azathioprine colace cytotec diamox duovir-n eldepryl exelon haldol loxitane nimotop persantine prograf seroquel strattera urso pain medicine anaprox celebrex deltasone feldene indocin isomonit isordil maxalt mobic motrin naprosyn paracetamol ponstel robaxin soma ultram penis enlargement andro-penis extender respiratory atrovent proventil serevent theo-24 skin care benzac daivonex differin elocon eurax cream eurax lotion oxsoralen renova temovate stop smoking zyban testosterone replacement increase theropy testosterone undecanoate-andriol 40mg thyroid synthroid weight loss florinef meridia sibutramine obestat ; xenical disclaimer policy our policies patient responsibility statement informed consent statemen terms and conditions patient responsibility statement by submitting this consultation form i affirm as if under oath and state truthfully that i a competent adult at least 18 years of age and meclizine.
Aptivus ; . Entry Inhibitors- none. Other- hydroxyurea Hydreea ; . OI DRUGS PHS "A1 OI"s- acyclovir Zovirax ; , azithromycin Zithromax ; , clarithromycin Biaxin ; , clindamycin Cleocin ; , fluconazole Diflucan ; , isoniazid INH ; , itraconozole Sporonox ; , leucovorin Wellcovorin ; , rifabutin Mycobutin ; , rifampin rimactane Rifidin ; , sulfadiazine Microsulfon ; , TMP SMX Bactrim, Septra ; , valgancyclovir Valcyte ; . Other OIs - ciprofloxacin Cipro ; , clotrimazole Mycelex ; , dapsone, ethambutol Myambutol ; , ketoconazole Nizoral ; , nystatin Mycostatin ; , Primaquine, trimethoprim Proloprim ; . ALL OTHERS megestrol acetate Megace ; , loperamide Imodium ; , pantoprazole Protonix ; , promethazine HCI Phenergan ; , Prenatal Vitamins, Vaccines for Hepatitis A&B.
She is 46 yrs old this is the current status: she had a lumpectomy diagnosis infiltrating and in situ ductal carcinoma 3cm size bloom richardson grade iii 2 ; with marked lymphopasmacytic reaction margins clear 2 sentinel nodes positive for metastic carcinoma 20 lymph nodes axillary dissection negative estrogen 80% progestorone 80% prolif 20% her-2 neu: the orginal core biopsy showed a fish of 55 suggesting positve the specimen was 1 + suggesting negative and antivert.
Contact your doctor immediately if you experience swelling of hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; hoarseness; or rash.
ANTIRETROVIRALS NRTIs- abacavir Ziagen ; , abacavir lamivudine Epzicom ; , abacavir lamivudine zidovudine Trizivir ; , didanosine ddI, Videx, Videx EC ; , emtricitabine Emtriva ; , lamivudine Epivir, 3TC ; , lamivudine zidovudine Combivir ; , stavudine d4T, Zerit ; , tenofovir Viread ; , tenofovir emtricitabine Truvada ; , zalcitabine ddC, Hivid ; , zidovudine AZT, Retrovir ; . PIs- amprenavir Agenerase ; , atazanavir Reyataz ; , fosamprenavir Lexiva ; , indinavir Crixivan ; , lopinavir ritonavir Kaletra ; , nelfinavir Viracept ; , ritonavir Norvir ; , saquinavir Fortovase, Invirase ; . NNRTIs- delavirdine Rescriptor ; , efavirenz Sustiva ; , nevirapine Viramune ; . Entry Inhibitorsenfuvirtide Fuzeon ; . Other-hydroxyurea Hydrea ; . OI DRUGS PHS "A1 OI"s- acyclovir Zovirax ; , amphotericin B Fungizone ; , azithromycin Zithromax ; , cidofovir Vistide ; , clarithromycin Biaxin ; , famciclovir Famvir ; , fluconazole Diflucan ; , foscarnet Foscavir ; , itraconazole Sporonox ; , leucovorin Wellcovorin ; , pyrimethamine Daraprim ; , sulfadiazine, TMP SMX Bactrim, Bactrim DS, Septra, SeptraDS, Sulfatrim ; . Other OIs- atovaquone Mepron ; , ciprofloxacin Cipro ; , clindamycin Cleocin ; , clotrimazole Lotrimin, Mycelex ; , dapsone, doxorubicin liposomal DOXIL ; , ethambutol Myambutol ; , filgrastim GCSF Neupogen ; , ketoconazole Nizoral ; , nystatin Mycostatin ; , pentamidine NebuPent, Pentam ; , primaquin, rifabutin Mycobutin ; , trimethoprim, valacyclovir Valtrex ; , valganciclovir Valcyte ; . Hepatitis C- none. TREATMENTS FOR METABOLIC DISORDERS Hyperlipidemia- atovastatin Lipitor ; , ezetimibe Zetia ; , fenofibrate Tricor ; , fluvastatin Lescol ; , gemfibrozil Lopid ; , lovastatin Mevacor ; , niacin Niaspan ; , pravastatin Pravachol ; , simvastatin Zocor ; . Wasting- megestrol acetate Megace ; . ALL OTHERS albuterol inhaled ; Ventolin; Proventil ; , amitriptyline Elavil ; , buproprion Wellbutrin SR ; , citalopram Celexa ; , escitalopram Lexapro ; , fentanyl Duragesic ; , fluoxetine Prozac ; , gabapentin Neurontin ; , Hepatitis A vaccine, Hepatitis B vaccine, ibuprofen Motrin ; , loperamide Imodium ; , morphine sulfate MS Contin ; , nefazadone Serzone ; , paroxetine Paxil ; , pneumococcal vaccines as outpatient treatment Pnemovax, Pnu-imune ; , polycarbophil Fibercon ; , psyllium Metamucil ; , sertraline Zoloft ; , trazodone Desyrel ; , venlaxafine Effexor and colace and Cheap hydrea.
And thou thyself who makest all men yellow, consuming them with burning heat. Thou, Fever! Then be weak and ineffective. Pass hence into the realms below or vanish. There are also charms for successful childbirth especially for sons for love affairs and the revival of virility, the Vedic equivalent of Viagra; for a long life, up to a "hundred autumns"; to expiate sins and create family harmony; to bring farmers rain, to protect shepherds and their herds from wild animals and merchants from robbers. There's even a charm to bring good luck to gamblers, which our woebegone friend from earlier might have tried when he visited the "gambling-house, " though apparently it didn't work very well. BRAHMANA The Brahmanas, so named because they were written by and for Brahmin priests, are prose commentaries that, by all accounts, are nearly as titillating as modern-day law books. There are about a dozen Brahmanas, each one appended to one of the samhitas, and each with two parts: a "rule" vidhi ; part, which details rules or regulations for the proper conduct of the rather complex ceremonies or sacrifices; and an expository part artha-vada ; , a what-not of explanations for the origins of the rituals and the legends connected with them. ARANYAKA The third layer of the Veda cake consists of the four surviving Aranyakas, the "forest" aranya ; books. Scholars assume these books were written by forest hermits, living rather spartan lives outside the pale not only of Vedic ritualism, but Vedic culture in general. They were, to use a modern phrase, true non-conformists. In the Aranyakas Unlike the pedantic Brahmanas, to which they are appended, the Aranyakas are meditations on the inner or psychological and mystical meaning and symbolism of the sacrifice.
ANTIRETROVIRALS NRTIs- abacavir Ziagen ; , abacavir lamivudine Epzicom ; , abacavir lamivudine zidovudine Trizivir ; , didanosine ddI, Videx, Videx EC ; , emtricitabine Emtriva ; , lamivudine Epivir, 3TC ; , lamivudine zidovudine Combivir ; , stavudine d4T, Zerit ; , tenofovir Viread ; , tenofovir emtricitabine Truvada ; , zalcitabine ddC, Hivid ; , zidovudine AZT, Retrovir ; . PIs- amprenavir Agenerase ; , atazanavir Reyataz ; , fos-amprenavir calcium Lexiva ; , indinavir Crixivan ; , lopinavir ritonavir Kaletra ; , nelfinavir Viracept ; , ritonavir Norvir ; , saquinavir Fortovase, Invirase ; . NNRTIs- delavirdine Rescriptor ; , efavirenz Sustiva ; , nevirapine Viramune ; . Otherhydroxyurea Hydrea ; . Entry Inhibitors- enfuvirtide Fuzeon ; . OI DRUGS PHS "A1 OI"s- acyclovir Zovirax ; , azithromycin Zithromax ; , cidofovir Vistide ; , clarithromycin Biaxin ; , famciclovir Famvir ; , fluconazole Diflucan ; , fomivirsen, foscarnet Foscavir ; , ganciclovir Cytovene ; , isoniazid INH ; , itraconazole Sporonox ; , leucovorin, probenecid, pyrimethamine Daraprim, Fansidar ; , sulfadiazine, TMP SMX Bactrim ; . Hepatitis C- all FDA approved drugs. ALL OTHERS Open Formulary - All FDA approved drugs are covered except the following: Specific open formulary exclusions: antirheumatic injectables e.g. Enbrel ; , botulinum toxin e.g. botox, mylobloc ; compounded medications for infusion active medication containing more than one ingredient ; , gonadotropin, finasteride Propecia ; , hyaluronic acid derivatives e.g. Hyalgan, Synvisc ; , immune globulin intravenous IGIV e.g. sandoglobulin, Venoglobulin ; , injectable muscle relaxants e.g. Lioresal ; , mifepristone, minoxidil Rogaine ; , monoclonal antibodies e.g. Remicade, Synagis ; , propoxyphene, recombinant human growth hormone HGH e.g. Geref, Humatrop ; , Viagra. Class Exclusions: cosmetic medications, durable medical equipment, erectile dysfunction pharamaceuticals, fertility drugs, herbal medications, immunizing biologicals, nutritional supplements and depakote.
About 15 years ago my fingernails started to get lengthwise ridges.
Sales of ADDERALL for the year ended 31 December 2002 were 9.8 million compared to 7.7 million in the comparative period. This decline in ADDERALL sales is largely due to the success in converting patients to the new, once-a-day formulation of the drug, ADDERALL XR. On a combined basis, product sales from the ADHD franchise in 2002 were up .4 million, a 22% increase compared to the prior year. Over the same period, the number of prescriptions written for ADDERALL XR and ADDERALL was marginally higher, by 0.6%. In December 2002, these products achieved a 28.8% share of the US ADHD prescription market December 2001: 34.4% ; . The total ADHD market grew by 14% during 2002 and thus provided further support to the excellent result in switching patients to ADDERALL XR. Our extended-release product ADDERALL XR is covered by a US patent. In January 2003 we received a Paragraph IV notice from Barr alleging that this patent is invalid and not infringed by Barr's extended-release mixed amphetamine salt product. In February 2003, Shire Laboratories Inc. filed suit against Barr for infringement of this US patent. For more details see note 19 to this report and financial statements. There can be no assurance that the Group will prevail in the suit and in the event it does not this may have a material adverse impact on the Group's results and financial position. AGRYLIN Total AGRYLIN sales for the year to 31 December 2002 were 9.2 million, an increase of 39% compared to the prior year 2001: .5 million ; . Underlying prescriptions for AGRYLIN in the US, where it is the only product licensed for the treatment of essential thrombocythaemia, increased by 22%. Shire achieved 26.5% of the total US AGRYLIN, hydrea and generic hydroxyurea prescription market in December 2002, compared to 24.4% in December 2001. PENTASA Sales of PENTASA, for the treatment of ulcerative colitis, were up 15% at .2 million 2001: .5 million ; . PENTASA had a prescription share of 17.6% of the US oral mesalamine olsalazine market in December 2002, compared with 18.6% in December 2001. PROAMATINE Sales of PROAMATINE, for the treatment of postural hypotension, were .9 million, 34% higher than 2001 sales of .0 million. The US prescription market for PROAMATINE and fludrocortisone acetate prescriptions indicated that PROAMATINE had a 25.3% market share for the month of December 2002, an increase from 23.6% in December 2001.
FDA asserts: "It is our understanding that BMS was made aware of these events on or before Sept. 24, 1999, but in the presentation on Sept. 28, the BMS representative discussed the use of hydroxyurea in HIV disease and promoted hydroxyurea as `very well tolerated.'" Information regarding a 1, 200 mg daily dose of hydroxyurea was also presented, despite greater toxicity of the drug at elevated doses. The warning letter summarizes: "Although BMS was aware of reports of serious adverse events and fatalities associated with the use of Hydrea or Droxia in the treatment of HIV disease, and knew that this information was not yet widely publicized in the medical literature, it did not disclose this information." Issuance of a warning letter suggests that FDA is remaining vigilant regarding promotions of off-label uses after the Washington Legal Foundation won a lawsuit against the agency that permitted fewer restrictions on offlabel promotions. However, the WLF decision requires that a promotional campaign for off-label use be grounded in articles that appeared in peer-reviewed journals or conferences.
Josef Seibt Viral vectors have become popular as vehicles to introduce genes for basic studies of protein function, vaccination, treatment of cancer and correction of genetic disorders. Viruses are "ideal" for this purpose since they have evolved efficient mechanisms to deliver nucleic acid to specific cell types while avoiding immunosurveillance by an infected host. A core facility for recombinant adenovirus construction has been established on an initiative from the Swedish Research Council, the Cancer Society, the Swedish Foundation for Strategic Research, and the Wallenberg Foundation. The facility has received funding to continue its operation during 2004. It will serve the Swedish academic research community, and is physically located at the renovated virus cell culture facility at IMBIM B11 corridor ; . At the facility recombinant viruses are reconstructed based on the so-called AdEasy and the transpose-Ad systems for further information see : qbiogene ; , although alternative viral vector backbones can be used. To restrict the usage of the core facility, customers are asked to transfer their gene of interest to a suitable shuttle vector provided by the facility ; . This will then be reconstructed to a virus at the facility. Investigators will receive a small-scale virus batch. It is important to note that the facility does not produce clinical grade viruses. : imbim.uu resource adenovirus.
The ITT analyses were supported by the analyses performed on patients completing treatment where weight reduction generally appeared somewhat more pronounced. The weight effects over time were very similar in the four studies and are presented in Figure 1 below with the RIO-Europe results. The weight reduction reached a plateau after approximately 36 weeks and buy dilantin.
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Model. J Pharm Assoc 2001; 41: 192. Perry , DP. When medicine hurts instead of helps. Consul Pharm. 1999; 14: 132630. Zagaria MA, Pharmaceutical care of the older patient. US. Pharmacist 2000, 25 2 ; : 94-95. Wilson IB, Schoen C, Neuman P, et al Physician-patient communication about prescription medication adherence: a 50-state study of America's seniors. J General Internal Medicine, 2007, 22: 6-12. Frazier SC. Health Outcomes and Polypharmacy in Elderly Individuals: An Integrated Review. J Gerotol Nurs 2005; 31: 4-11. Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med. 2003; 163: 27162724.
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Hydroxyurea generic name ; is manufactured as Droxia trade name ; Bristol-Myers Squibb, Princeton, NJ ; , Hydrea trade name ; Bristol-Myers Squibb ; , and MylocelTM trade name ; mgI Pharma, Bloomington, MN ; . regular dosing schedule. Do not double doses. If you accidentally take too many pills or someone else accidentally takes your medicine, contact your doctor or the nearest emergency room immediately.
Still, it isn't outrageous to conclude that a multivitamin may be a good idea in a disease that often results in nutritional deficiencies and a potentially fatal wasting.
ANTIRETROVIRALS NRTIs- abacavir Ziagen ; , abacavir lamivudine Epzicom ; , abacavir lamivudine zidovudine Trizivir ; , didanosine ddI, Videx, Videx EC ; , emtricitabine Emtriva ; , lamivudine Epivir, 3TC ; , lamivudine zidovudine Combivir ; , stavudine d4T, Zerit ; , tenofovir Viread ; , tenofovir emtricitabine Truvada ; , zalcitabine ddC, Hivid ; , zidovudine AZT, Retrovir ; . PIs- amprenavir Agenerase ; , atazanavir Reyataz ; , fosamprenavir Lexiva ; , indinavir Crixivan ; , lopinavir ritonavir Kaletra ; , nelfinavir Viracept ; , ritonavir Norvir ; , saquinavir Invirase ; , tipranavir Aptivus ; . NNRTIs- delavirdine Rescriptor ; , efavirenz Sustiva ; , nevirapine Viramune ; . Other- hydroxyurea Hydrea ; . Entry Inhibitors- enfuvirtide Fuzeon ; . OI DRUGS PHS "A1 OI"s- acyclovir Zovirax ; , azithromycin Zithromax ; , clarithromycin Biaxin ; , famciclovir Famvir ; , fluconazole Diflucan ; , isoniazid INH ; , itraconozole Sporanox ; , leucovorin, pentamidine Pentam ; , pyrimethamine Daraprim ; , rifabutin Mycobutin ; , sulfadiazine, TMP SMX Bactrim ; , valacyclovir Valtrex ; , valganciclovir Valcyte ; . Other OIs- atovaquone Mepron ; , clotrimazole Mycelex ; , dapsone, ethambutol Myambutol ; , ketoconazole Nizoral ; , nystatin Nilstat ; . TREATMENTS FOR METABOLIC DISORDERS Diabetes - acarbose Precose ; , glipizide Glucotrol ; , metformin HCl Glucophage ; , rosiglitazone maleate Avandia ; . Hyperlipidemia - atorvastatin Lipitor ; , fenofibrate Tricor ; , gemfibrozil Lopid ; , lisinopril generic only ; , pravastatin Pravachol ; , rosuvastatin calcium Crestor ; . Wasting - testosterone Androgel, Testaderm, androderm patches, Testim ; . ALL OTHERS amitriptyline Elavil ; , atropine diphenoxylate Lomotil ; , bupropion Wellbutrin ; , citalopram Celexa ; , DepoProvera vial ; , desipramine Norpramin ; , divalproex sodium Depakote ; , fluoxetine Prozac ; , Hep A Vaccine Havrix ; , Hep B Vaccine Engerix, Recombivax, Twinrix ; , imiquimod Aldara Cream ; , medroxyprogesterone acetate injectable suspension Depo-Provera ; , mirtazapine Remeron ; , nefazodone Serzone ; , nizatidine Axid ; , loperamide Immodium ; , omeprazole Prilosec ; , paroxetine Paxil ; , penicillin G benthazine Bicillin LA ; , prochlorperazine Compazine ; , promethazine Phenergan ; , ranitidine Zantac ; , risperidone Risperdal ; , sertraline Zoloft ; , trazadone Desyrel, Trialodine ; , venlafaxine Effexor.
US Food and Drug Administration21 HT products are effective in treating moderate to severe vasomotor symptoms and moderate to severe vaginal dryness and in preventing osteoporosis associated with menopause. If HT is prescribed solely for vaginal dryness, topical hormone therapies should be considered instead. If HT is prescribed solely for prevention of osteoporosis, other treatments should be considered first, and the severity of risk should be significant. If HT is prescribed, it should be used at the lowest effective dose and for the shortest possible duration to reach treatment goals.
The goal of treatment is palliation. With chemotherapy, the patient may be kept asymptomatic for long periods by keeping the white blood cell count below 50, 000 uL. Several prescription medications may be used Table 1 ; . Table 1. Conventional Medications used in the Treatment of Chronic Myelogenous Leukemia Hydroxyurea Hydrea ; is currently the cytotoxic agent of choice. It blocks ribonucleotide reductase, impairing DNA but not RNA ; synthesis. Busulfan Myleran ; is an alkylating agent whose activity is mostly seen in myeloid cells and hematopoetic stem cells. It was commonly used during the chronic phase. Plicamycin Mithracin, Mithramycin ; inhibits DNA synthesis and DNA-dependant RNA synthesis. Vincristine Oncovin ; is an antineoplastic agent approved for acute lymphocytic leukemia ALL ; . Interferon alfa Alferon, Intron, Roferon ; is an immunomodulator that has been shown to produce remission with disappearance of Philadelphia-chromosome positive cells in the marrow in some patients, but the long-term benefit is not yet known. Allopurinol may be recommended to reduce uric acid levels.
In the ACTG 076 trial, ZDV monotherapy was intended to decrease mother to child transmission of HIV and was not prescribed to stabilize the health of women with HIV infection. Now with the demonstration of the superiority of combination therapy or highly active antiretroviral therapy, HAART ; compared to antiretroviral monotherapy, ZDV therapy alone is now considered sub optimal for the treatment of HIV infection. Antiretroviral monotherapy should only be considered for pregnant women for whom combination antiretroviral therapy is not indicated or has been refused. The Pediatric AIDS Clinical Trials Group 076 Zidovudine ZDV ; Regimen: Adopted from the Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1 Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV-1 Transmission in the United States, June 16, 2003. Throughout pregnancy, clinicians should evaluate women with HIV infection for clinical and immunologic disease progression and for the need for antiretroviral therapy for maternal indications. In women with advanced immunosuppression, antiretroviral therapy for maternal indications should be recommended after consultation with a physician skilled in AIDS medicine. Effective and durable HIV therapy maximally suppresses viral replication while sustaining immune function and reducing the development of resistance. Current guidelines for antiretroviral therapy balance the benefit of potent therapy with the risk of long-term side effects and the possible emergence of drug resistance. Use of antiretroviral therapy in pregnancy combines their use to improve the health of the woman with their use to reduce perinatal transmission. Current treatment recommendations for HIV-1-infected pregnant women are based on the belief that therapies of accepted benefit to women should not be withheld during pregnancy unless there are documented adverse effects on the mother, fetus, or infant and these adverse effects outweigh the benefit to the woman. Since there is no compelling evidence of additional risk or data to support a therapeutic advantage to the use of an alternative therapy, the guidelines for optimal antiretroviral therapy in pregnant HIV-1-infected women should be the same as those delineated for non-pregnant adults. These complex regimens should be initiated and managed in consultation with clinicians experienced in HIV AIDS care. Caregivers should not forget that the potential impact of optimal therapy on the fetus and infant is unknown. Long-term follow-up is needed for children who have exposure to antiretroviral drugs in utero. Therefore, any decision to use any antiretroviral drug during pregnancy should be made by the woman following discussion with her health care provider regarding the known and unknown benefits and risks to her and her fetus. Potent combination therapy usually includes at least 3 medications: two from the class of nucleoside analogue reverse transcriptase inhibitors NRTI ; and one from either the non-nucleoside reverse transcriptase inhibitor class NNRTI ; or the protease inhibitor class PI ; . However, some adjustments may be made during pregnancy, for example, avoidance of the teratogenic drugs efavirenz Sustiva ; and hydroxyurea Hydrea ; . Certain combinations of three nucleoside analogues have been proven to be less potent and durable than combinations including an NNRTI or PI. When constructing an antiretroviral regimen for a HIV positive pregnant woman, please consult The United States Public Health Task Force Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV-1 Transmission in the United States, June 16, 2003 at : aidsinfo.nih guidelines. Passage of antiretroviral drugs into breast milk has been evaluated for only a few antiretroviral drugs. ZDV, 3TC, and Nevirapine can be detected in the breast milk of women, and ddI, d4T, Abacavir, Delavirdine, Indinavir, Ritonavir, Saquinavir and Amprenavir can be detected in the breast milk of lactating rats. Limited data are available regarding either the efficacy of antiretroviral therapy for the prevention of postnatal transmission of HIV-1 through breast milk or the toxicity of long-term antiretroviral exposure of the infant through breast milk. Women who must temporarily discontinue therapy because of pregnancy-related hyperemesis should not resume therapy until sufficient time has elapsed to ensure that the drugs will be tolerated. To reduce the potential for emergence of resistance, if therapy requires temporary discontinuation for any reason during pregnancy, all drugs should be stopped and reintroduced simultaneously. Preliminary data suggest that pre-existing ZDV resistance among previously treated women is associated with reduced efficacy of the ACTG 076 regimen. Therefore, women who have received prior ZDV therapy should be considered for combination antiretroviral treatment. Some women may acquire ZDV resistance without prior treatment.
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RETINAL ARTERY OCCLUSION IS A MARKER OF SIGNIFICANT CAROTID ARTERIES AND HEART DISEASE. S. Krishnan, C.A. Roldan, A. Das, University of New Mexico and New Mexico VA Health Care System, Albuquerque, NM. Background: Retinal artery occlusion RAO ; is believed to result from carotid arteries atheroemboli, and uncommonly from cardioembolism. Therefore, it is routine practice to perform carotid duplex, transthoracic echocardiography TTE ; , and electrocardiography ECG ; in these patients, but limited data are available about the diagnostic yield of these techniques. Methods: After ophthalmic diagnosis of RAO, 28 patients age, 50 to 85 years ; underwent carotid arteries duplex, TTE, and ECG. Experienced observers interpreted all studies. Carotid artery disease was graded as 0 normal ; , I mild intimae irregularities and 15% stenosis ; , II 16%-49% stenosis ; , III 50%-79% stenosis ; , and IV 80% stenosis ; . Cardioembolic substrate CES ; was defined as left ventricular LV ; ejection fraction EF ; 35%, LV aneurysm, or LV left atria thrombi, and atria fibrillation AFib ; . Results: Of the 28 patients studied, 23 82% ; had branch RAO and five 18% ; had central RAO p 0.01 ; . Fourteen patients 50% ; had grade II to IV carotid artery disease and 7 patients 25% ; had CES p 0.09 ; . Among the 14 patients with carotid artery disease, 6 43% ; underwent carotid endarterectomy. Among the 7 with CES, 3 had LVEF 35%, 2 had cardiac thrombus, 1 had Afib, 1 had Afib and LVEF 35%. Two patients with CES also had significant carotid disease. Conclusions: In patients with retinal artery occlusion, 1 ; significant carotid artery disease is highly prevalent and the predominant thromboembolic source; and 2 ; significant heart disease and substrates for embolism are also common. Thus, retinal artery occlusion is a marker of underlying significant carotid arteries and heart disease.
Table 1. Demographic data and patient characteristics. Diagnosis Sex ET Ph + Cml MF male female median range average 45 years 45 years Hydrea only IFN-Hydrea young age resistance intolerance development of inv16 median range average 500x109 l 500x109 l median 550x109 l range 240-2.100x109 l average 600x109 l 19 22 86.4% ; 2 22 9% ; 1 22 4.6% ; 11 22 50% ; 11 22 50% ; 57 years 17-81 years 57 years 6 22 27.3% ; 16 22 72.7% ; 10 22 45.5% ; 12 22 54.5% ; 7 22 31.8% ; 6 22 27.3% ; 8 22 36.4% ; 1 22 4.5% ; 4.8 years 4 months-12.8years 5.5 years 10 22 45.5% ; 12 22 54.5.
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